Adapalene | Health Navigator NZ

November 20, 2022

Adapalene | Health Navigator NZ

Looking for:

Differin on broken skin -

Often side effects improve as your body gets used to the new medicine. Looking for Where to get medical help A health professional or service Patient portals Newsletters View all.

Treatment for acne Belongs to a group of medicines known as retinoids. Redness or burning feeling on your skin Dry skin Skin peeling Flare up of acne. These may go away with time. Try applying adapalene less often — see 'Special instructions' above. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes.

The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use. Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment. Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use.

Not to be used in patients who are hypersensitive to the active substance or any of the excipients. For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasions , sunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body.

If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body.

If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether. If patients use cosmetics, these should be noncomedogenic and nonastringent. Only oil free moisturisers should be used to relieve dry facial skin. Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects.

Animal studies on compounds with a similar mode of action to adapalene have suggested that these may enhance the development of skin cancers caused by UV light. Adapalene is essentially stable to oxygen and light and is chemically nonreactive. Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies.

The safety of using adapalene during long or repeated exposures to sunlight or UV radiation has not been established in animals or humans. Exposure to sunlight or UV irradiation including sunlamps should be avoided during treatment with adapalene. Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied.

Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed.

Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied. Effects on laboratory tests. There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene.

Exposure of adapalene to other topical antiacne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low see Section 5. Differin topical cream has potential for local irritation and it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects.

Effects on fertility. In addition the incidences of various skeletal variations were increased at lower oral doses in rats. Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment.

Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration. A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application.

Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established. Side effects. Redness, dry skin, burning sensation at the site of application and scaling. Skin irritation, pruritus and sunburn. Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule.

See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation. Body as a whole. Immune system disorders. Skin and subcutaneous tissue disorders. These events often spontaneously resolve upon adaptation to therapy regimen. Reporting suspected adverse effects. Reporting suspected adverse reactions after registration of the medicinal product is important.

It allows continued monitoring of the benefit-risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions at www. Differin Topical cream is intended for topical use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur. Differin topical cream is not to be taken orally.

Unless the amount accidentally ingested is small, an appropriate method of gastric emptying should be considered. For information on the management of overdose, contact the Poisons Information Centre on Australia.

Overall, results from the consumer studies showed that consumers can understand the information on the OTC label, appropriately select whether the product is right for them, and use the product appropriately. The maximal use trial, a study of absorption of the drug through acne-affected skin when applied daily over a large surface area face, shoulders, upper back and chest , demonstrated that absorption is limited, thus supporting safe use of Differin Gel 0.

Consumers should follow the Drug Facts label and consult with their health care providers if their symptoms do not improve. The drug should be applied once daily in a thin layer on the affected areas of skin, and it is for external use only. People using Differin Gel 0. In the first few weeks of use, skin may become irritated redness, itching, dryness, burning. Consumers should stop use and ask a doctor if irritation becomes severe, if there is no improvement in acne after three months of daily use, if symptoms of allergic reaction appear, or if they become pregnant or are planning to become pregnant while using the drug.

The FDA, an agency within the U.

❿

- Differin on broken skin

Ask your doctor or pharmacist if you are not sure how much to apply. They will tell you exactly how much to use for each application. Avoid the use of of oil-based makeups and creams. Cosmetic products with an abrasive, drying or peeling action may cause an extra irritant effect. Pimples and spots will be reduced only after several application of this medicine. It may take weeks to notice an improvement and more improvement after further use.

If it is almost time for your next dose, skip the dose you missed and use your next dose when you are meant to. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily. Minimise exposure to sunlight and UV lamps. Protect your skin when you are in the sun, especially between 10 am and 3 pm. All medicines may have some unwanted side effects. Sometimes they are serious, but most of the time they are not. Your doctor has weighed the risks of using this medicine against the benefits they expect it will have for you.

Do not be alarmed by this list of possible side effects. You may not experience any of them. Tell your doctor as soon as possible if you notice any of the following and they worry you:.

If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the cream less often, or to stop using it until symptoms subside. These are very serious side effects.

You may need urgent medical attention or hospitalisation. Tell your doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some patients. If you have queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your doctor or pharmacist.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel. Excipients with known effect. Methyl hydroxybenzoate, propyl hydroxybenzoate.

For the full list of excipients see Section 6. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes. The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use.

Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment. Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use.

Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body. If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.

If patients use cosmetics, these should be noncomedogenic and nonastringent. Only oil free moisturisers should be used to relieve dry facial skin. Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects. Animal studies on compounds with a similar mode of action to adapalene have suggested that these may enhance the development of skin cancers caused by UV light.

Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied.

Effects on laboratory tests. There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene. Exposure of adapalene to other topical antiacne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low see Section 5.

Differin topical cream has potential for local irritation and it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects. Effects on fertility. In addition the incidences of various skeletal variations were increased at lower oral doses in rats. Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment.

The U. Food and Drug Administration today approved Differin Gel 0. Differin Gel 0. Acne is a common skin disease that affects approximately 50 million people in the United States. Acne pimples form when hair follicles of the skin clog up. Generally, pimples form on the face, neck, back, chest and shoulders. Anyone can get acne, but it is most common in teenagers and young adults. Acne can cause scarring and have adverse psychological effects for example, poor self-image, depression and anxiety.

Like all medicines, adapalene can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine. Looking for Where to get medical help A health professional or service Patient portals Newsletters View all.

Treatment for acne Belongs to a group of medicines known as retinoids. Redness or burning feeling on your skin Dry skin Skin peeling Flare up of acne.

These may go away with time.

❾-50%}

- Differin on broken skin

The relevance of the finding in male rats to the use of Differin Topical cream in acne vulgaris is not known.

Adapalene also has anti-inflammatory properties, so it reduces the soreness and irritation of acne. In New Zealand adapalene is available in a cream or gel. The gel is suitable for most people but those with dry skin may prefer the cream.

Discuss the best choice with your doctor. Read more about acne. Like all medicines, adapalene can cause side effects, although not everyone gets them.

Often side effects improve as your body gets used to the new medicine. Looking for Where to get medical help A health professional or service Patient portals Newsletters View all.

Treatment for acne Belongs to a group of medicines known as retinoids. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.

Adapalene is essentially stable to oxygen and light and is chemically nonreactive. Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies. The safety of using adapalene during long or repeated exposures to sunlight or UV radiation has not been established in animals or humans. Exposure to sunlight or UV irradiation including sunlamps should be avoided during treatment with adapalene.

Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied. Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied.

Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment. In case of unexpected pregnancy, treatment should be discontinued. It is not known whether adapalene is excreted in human milk.

Therefore, the preparation should be used with caution in nursing mothers, and only on areas away from the chest. Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration. A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application.

Skin irritation, pruritus and sunburn. Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule. See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation.

Body as a whole. Immune system disorders. Skin and subcutaneous tissue disorders. These events often spontaneously resolve upon adaptation to therapy regimen. Reporting suspected adverse effects. Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product.

Healthcare professionals are asked to report any suspected adverse reactions at www. Differin Topical cream is intended for topical use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur. Differin topical cream is not to be taken orally. Unless the amount accidentally ingested is small, an appropriate method of gastric emptying should be considered.

For information on the management of overdose, contact the Poisons Information Centre on Australia. Mechanism of action. Adapalene is a chemically stable compound with retinoid-like pharmacological activity. Biochemical and pharmacological profile studies have demonstrated that adapalene is a potent modulator of cellular differentiation, keratinisation and inflammatory processes all of which represent important features in the pathology of acne vulgaris.

Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but unlike tretinoin, does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, current evidence suggests that topical adapalene normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Adapalene inhibits the chemotactic directional and chemokinetic random responses of human polymorphonuclear leucocytes in in vitro assay models. It also inhibits the metabolism of arachidonic acid by lipoxidation, to inflammatory mediators. Clinical trials. The efficacy of Differin cream has been assessed in 2 randomised, double blind, parallel comparison clinical trials. In the first trial, subjects with acne vulgaris associated with at least 20 facial noninflammatory comedones and 10 inflammatory lesions were enrolled for treatment with Differin cream or the cream vehicle administered once daily.

In the second trial, subjects with acne vulgaris were enrolled for treatment with Differin cream or tretinoin cream 0. In clinical trials adapalene was seldom detected in plasma, and then only in trace amounts following chronic topical application with an analytical limit of quantification of 0.

After administration of 14 C-adapalene to rats, rabbits and dogs, radioactivity was distributed in several tissues, the highest levels being found in liver, spleen, adrenals and ovaries.

Metabolism in animals is maintained by O-demethylation, hydroxylation and conjugation, and excretion is primarily by the biliary route.

In a human study performed using the gel formulation in which male volunteers followed a course of exaggerated topical application, 30 g a full tube was applied all over the body each day for 7 consecutive days, the resultant circulating plasma levels were below the limit of detection 0.

There were low quantities of the parent substance in the faeces. In another study healthy volunteers used radiolabelled adapalene 0. The other 4 subjects received a single topical application of the radiolabelled product. Levels of radioactivity in all plasma, urine, faeces and skin strip samples analysed were below the limits of reliable quantification, indicating that either very little or no radioactivity was absorbed through the skin.

A further study carried out to investigate the distribution of adapalene in the adipose tissue of women after repeated daily application of adapalene gel for 3 months, found that there was no evidence of circulating adapalene in the plasma limit of detection 0.

On day 90, adapalene levels in the adipose tissue were not quantifiable in 5 of the 6 volunteers limit of detection 1 nanogram. In the 6th volunteer the mean concentration at 3 sites was 1. These concentrations were no longer evident when re-evaluated at the same sites in this subject 1 month after the cessation of treatment.

Adapalene did not demonstrate mutagenic or clastogenic activity in in vitro tests with bacterial and mammalian cells and showed no clastogenic activity in mammalian cells in vitro and an in vitro test in mice.

Lifetime studies with adapalene have been completed in mice at topical doses of 0. Phaeochromocytomas were observed in the adrenal medulla of male rats dosed at 1. This finding was not observed in female rats or in mice. The relevance of the finding in male rats to the use of Differin Topical cream in acne vulgaris is not known. Carbomer P, PEG methyl glucose sesquistearate, glycerol, squalane, methyl hydroxybenzoate, propyl hydroxybenzoate, disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide, purified water.

Incompatibilities were either not assessed or not identified as part of the registration of this medicine. The expiry date can be found on the packaging. Avoid exposure to excessive heat. Replace cap tightly after use. Collapsible aluminium tube 3 g, 5 g, 30 g and 50 g coated internally with an epoxy-phenolic resin and fitted with a white polypropylene screw cap.

AUST R Not all pack sizes may be marketed. In Australia, any unused medicine or waste material should be disposed of by taking to your local pharmacy. Common name. Chemical structure. Chemical name. Molecular formula. Molecular weight. CAS number. Reasonable care is taken to provide accurate information at the time of creation. This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition. NPS MedicineWise disclaims all liability including for negligence for any loss, damage or injury resulting from reliance on or use of this information.

It does not contain all the available information. It does not use the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. The product acts against the abnormal skin processes associated with acne. If it has expired or is damaged, return it to your pharmacist for disposal.

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. DIFFERIN gel contains methyl hydroxybenzoate E which may cause allergic reactions possibly delayed and propylene glycol which can cause skin irritation. Tell your doctor if you are pregnant or plan to become pregnant. Your doctor can discuss with you the risks and benefits involved.

Tell your doctor if you are breast-feeding or planning to breast-feed. Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. Ensure that the affected areas are dry before application. Ask your doctor or pharmacist if you are not sure how much to apply.

They will tell you exactly how much to use for each application. Avoid the use of of oil-based makeups and creams. Cosmetic products with an abrasive, drying or peeling action may cause an extra irritant effect. Pimples and spots will be reduced only after several application of this medicine. It may take weeks to notice an improvement and more improvement after further use. If it is almost time for your next dose, skip the dose you missed and use your next dose when you are meant to.

Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily. Minimise exposure to sunlight and UV lamps. Protect your skin when you are in the sun, especially between 10 am and 3 pm.

All medicines may have some unwanted side effects. Sometimes they are serious, but most of the time they are not. Your doctor has weighed the risks of using this medicine against the benefits they expect it will have for you.

Do not be alarmed by this list of possible side effects. You may not experience any of them. Tell your doctor as soon as possible if you notice any of the following and they worry you:. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the cream less often, or to stop using it until symptoms subside. These are very serious side effects. You may need urgent medical attention or hospitalisation.

Tell your doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some patients. If you have queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your doctor or pharmacist. Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel.

Excipients with known effect. Methyl hydroxybenzoate, propyl hydroxybenzoate. For the full list of excipients see Section 6. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes.

Not to be used in patients who are hypersensitive to the active substance or any of the excipients. For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasionssunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body.

If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.

In case of unexpected pregnancy, treatment should be discontinued. It is not known whether adapalene is excreted in human milk. Therefore, the preparation should be used with caution in nursing mothers, and only on areas away from the chest. Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding.

The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration. A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application. Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established. Side effects. Redness, dry skin, burning sensation at the site of application and scaling.

localhost › Treatments › Acne › Differin. DIFFERIN topical cream % is indicated for the topical treatment of comedo, membranes, angles of the nose or broken skin (cuts and abrasions). ️ Don't apply Differin to broken, sunburnt or sensitive areas of skin, or skin affected by eczema. Also take care to avoid getting it on your. The drug should be applied once daily in a thin layer on the affected areas of skin, and it is for external use only. Differin Gel % should. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Differin. Return any unused medicine to your pharmacist. This finding was not observed in female rats or in mice. DIFFERIN gel contains methyl hydroxybenzoate E which may cause allergic reactions possibly delayed and propylene glycol which can cause skin irritation. Reporting suspected adverse reactions after registration of the medicinal product is important.

Adapalene is used to treat acne. Find out how to apply it safely and possible side effects. Adapalene is also called Differin. Adapalene is used to treat acne blackheads, whiteheads, pimples on the face, chest or back. It works by unblocking the pores on the skin and in this way prevents blackheads and whiteheads. Adapalene also has anti-inflammatory properties, so it reduces the soreness and irritation of acne.

In New Zealand adapalene is available in a cream or gel. The gel is suitable for most people but those with dry skin may prefer the cream. Discuss the best choice with your doctor. Read more about acne.

Redness or burning feeling on your skin Dry skin Skin peeling Flare up of acne. These may go away with time. Try applying adapalene less often — see 'Special instructions' above. Tell your doctor if your acne doesn't go away, is painful or bothering you. Report a side effect to a product.

Search This Blog

244tabulme-eby